07/08/2024 - Our manuscript is accepted in the Journal of Chemical Theory and Computation.

In this work we describe a computational pipeline to detect energy sensitve points in protein structures that mediate allostery and cooperativity. Congratulations to Dan Burns that single handedly completed this project.

05/21/2024 - Our manuscript is accepted in PNAS.

In this work we describe how an alpha-ketoglutarate conformational change controls activation and substrate selectivity of the human RNA demethylase FTO. Congratulations to Dan Burns and Bal Khatiwada who co-first authored this project.

04/18/2024 - Congratulations to Kyle Malcolm who has successfully defended his Master Thesis.

04/16/2024 - Congratulations to Dr. Dan Burns who has successfully defended his Ph.D.

03/22/2024 - Our manuscript is accepted in the Journal of Molecular Biology.

In this work we combine high pressure NMR and SAXS with MD siumulations to investigate the structure and thermodynamics of the monomer-dimer equilibrium in full-lenght bacterial Enzyme I. Congratulations to Sergey Sedinkin for this achievement!

11/09/2023 - Our manuscript is accepted in Chemical Science.

In this work we use surface contrast solution NMR and reaction kinetic assays to characterize how hydrogen spillover mediates the phenol hydrogenation reaction catalyzed by Pd on reducible metal oxides. Congratulations to Yeongseo An and Puranjan Chatterjee who co-first authored this manuscript!

10/13/2023 - Our manuscript is accepted in PLoS Computational Biology.

In this work we describe how mapping temperature sensitive contacts raveals the allosteric network that gates the TRPV3 ion channel. Congratulations to Dan Burns who soloed this poject!

05/24/2023 - Our manuscript is accepted in JACS.

In this work we describe an open-source computational pipeline for generating conformational ensembles consistent with RDC NMR data from protein sequence alone. Congratulations to Sergey Sedinkin and Dan Burns!

03/26/2023 - Congratulations to Aayushi Singh who was awarded the ISU Teaching Excellence Award

04/06/2023 - Congratulations to Dr. Yeongseo An DiLorenzo who has successfully defended her Ph.D.

03/03/2023 - We are have received notice that our R35 MIRA grant from the National Institute of General Medical Sciences will be renewed until May 2028.

Project Title: Atomic-level characterization of self-regulatory mechanisms in large multidomain enzymes.

01/10/2023 - Our manuscript is accepted as a Feature Paper in Biomolecules.

In this work we describe how residual conformational dynamics underlie selective recognition of thermophilic over mesophilic Enzyme I by a substrate analogue. Congratulations to Aayushi Singh, Dan Burns and Sergey Sedinkin for this acievement.

01/02/2023 - Baboucarr joins the lab

01/02/2023 - Dilini joins the lab

01/02/2023 - Sayan joins the lab

10/11/2022 - Our manuscript is accepted in PNAS.

In this work we describe a computational approach to identify temperature-sensitive contacts in disordered loops that tune enzymatic activity. Congratulations to Dan Burns and Aayushi Singh for this acievement.

08/15/2022 - Congratulations to Yeongseo An for being awarded the best poster presentation at the 2022 meeting of the Great Plains Society fo Catalysis

06/10/2022 - Aayushi Singh presents her work at the first Ames Local NMR Symposium

05/09/2022 - Our manuscript is accepted in RCS Nanoscale Advances.

In this review we summarize solution NMR methods for investigating nanoparticle adsorption. A big THANK YOU to Yeongseo An and Sergey Sedinkin for their meticolous work.

04/05/2022 - Vincenzo gives a tutorial seminar at the "Global NMR Discussion" webinar series

04/05/2022 - Our manuscript is accepted in the Journal of Biological Chemistry.

In this work we determine a solution structure ensemble for the obesity-associated human FTO and highlight novel druggable pokets at the interface between N- and C-terminal domain. Congratulations to Bal Khatiwada for leading this team effort.

02/24/2022 - Vincenzo gives a seminar at "Emerging Topics in Biomolecular Magnetic Resonance"

01/02/2022 - Kyle joins the lab

12/03/2021 - Congratulations to Dr. Bal Khatiwada who has successfully defended his Ph.D.

10/22/2021 - Yeongseo An presents her work at the ACS 2021 Midwest Regional Meeting

10/21/2021 - Bal Khatiwada presents his work at the ACS 2021 Midwest Regional Meeting

09/13/2021 - The Venditti Lab is the recipient of the 2021 Trapp Innovation award

The award provides funding to a faculty member who is pursuing new or unique research in chemistry or the physical sciences.

07/29/2021 - Our collaborative work with the Slowing's group is accepted for publication in ACS Catalysis

We describe the mechanism by which ceria-supported palladium catalyzes the hydrodehalogenation of halophenols.

06/29/2021 - Our manuscript is accepted in Science Advances.

In this work, we use NMR and MD simulations to investigate the molecular mechanisms underlying activation of the human RNA demethylase Alkbh5. We show that binding of the methylated substrate induces a metal-centered conformational rearrangement that activates catalysis and confers substrate selectivity to Alkbh5. Congratulations to Jeff Purslow, Trang Nguyen, Bal Khatiwada and Aayushi Singh for completing this work.

06/29/2021 - Our manuscript is accepted in Frontiers Molecular Biosciences.

In this work, we characterize the link between the kinetics of the of the g⁺-to-g^- rotameric transition of bacterial Enzyme I and its enzymatic activity. In addition, we describe how to engineer hybrid mesophilic/thermophilic chimeras that assist investigations of the dynamics/function relationship in proteins. Congratulations to Jeff Purslow, Jolene Thimmesch, Valeria Sivo, Trang Nguyen, Bal Khatiwada, and Rochelle Dotas for this accomplishment.

04/16/2021 - Congratulations to Yeongseo An who was awarded the ISU Teaching Excellence Award

04/14/2021 - Congratulations to Vincenzo who was promoted to the rank of Associate Professor with tenure for the 2021-2022 academic year.

A big THANK YOU to all students and collaborators that have contributed with their hard work.

04/14/2021 - Our manuscript is accepted in PNAS.

In this work we use high-pressure NMR to investigate the link between oligomerization and enzymatic activity in bacterial Enzyme I. Congratulations to Trang Nguyen for completing this impressive project.

04/07/2021 - Congratulations to Dr. Trang Nguyen who has successfully defended her Ph.D.

02/09/2021 - Our manuscript is accepted in the Journal of Visualized Experiments.

In this invited work we describe the protocol implemented in our lab for acquisition and analysis of ¹⁵N relaxation dispersion experiments on large proteins. A big THANK YOU to Aayushi Singh and Jeff Purslow for their hard work on this project.

01/14/2021 - Congratulations to Dr. Ld. Jeffrey Purslow who has successfully defended his Ph.D.

11/06/2020 - Our manuscript is accepted in the Journal of Magnetic Resonance.

We introduce a library of organic gelators to stabilize nanoparticle suspensions in non-aqueous environment. Congratulations to Sergey Sedinkin and Yeongseo An for completing this work that opens new research directions in the lab.

10/21/2020 - Our manuscript is accepted in ACS Applied Nano Materials.

In this work we describe the use of ¹³C ΔR₂ data to obtain semiquantitative analysis of sorption equilibria. Congratulations to Yeongseo An for this fantastic achievement!

10/09/2020 - Bal Khatiwada presents his work at the 13^th GRASP Symposium. Congratulations to Bal for giving a great webinar!

10/02/2020 - Vincenzo gives his tenure seminar

09/11/2020 - The Venditti lab trains for happines!

08/13/2020 - Our collaborative work with the Fawzi's group is accepted for publication in Nucleic Acids Research

We describe the effect of hnRNPA2-RNA on liquid-liquid phase separation and aggregation.

08/03/2020 - Sergey joins the lab

07/17/2020 - Our manuscript is accepted in the Journal of Structural Biology X.

In this work we describe a number of potential leads for Enzyme-I inhibitors, which could constitute an attractive broad-spectrum antibacterial target. Congratulations to Trang Nguyen for having completed this challenging project!.

05/29/2020 - Our manuscript is accepted in the Journal of Molecular Biology.

In this work we use NMR, crystallography, MD simulations, enzymology, and protein engineering to show how bacterial Enzyme I is thermodynamically regulated by structural heterogeneity in the active site. Congratulations to Rochelle Dotas for having lead such multidisciplinary effort!.

05/08/2020 - Our manuscript is accepted in ChemCatChem.

In this work we show how modern solution NMR methods can be used to understand interfacial reaction mechanisms with atomic resolution. In addition, we reveal an active role for ceria in the Pd/CeO₂-catalyzed hydrogenetation of phenol. Congratulations to Tim Egner and Pranjali Naik for this accomplishment!.

04/15/2020 - Congratulations to Dr. Rochelle Dotas who has successfully defended her Ph.D.

03/30/2020 - Congratulations to Trang Nguyen who received the 2020 Esther P. and George E. Daniel Endowed Scholarship

03/30/2020 - Congratulations to Bal Khatiwada who was awarded the ISU Teaching Excellence Award

01/10/2020 - Our manuscript is accepted in Frontiers Molecular Biosciences.

In this mini-review we summarize advanced NMR methods for characterization of protein-protein interactions. A big THANK to Jeff Purslow and Bal Khatiwada who put a lot of effort in assembling this manuscript!.

01/02/2020 - Aayushi joins the lab

01/02/2020 - Dan joins the lab

11/22/2019 - The Venditti lab attends the 12^th GRASP Symposium on Protein and Biomolecular NMR

Proud of Trang Nguyen who won best oral presentation award!

11/15/2019 - Congratulation to Dr. Tim Egner who has successfully defended his Ph.D.

11/14/2019 - Our manuscript is accepted in Protein Expression and Purification.

In this work we describe the use of the N-terminal domain of Enzyme I as an efficient solubility tag for recombinant expression in E. coli. Congratulations to Bal Khatiwada and Jeff Purslow for having completed this project!.

07/30/2019 - We are awarded an R35 MIRA grant from the National Institute of General Medical Sciences

Project Title: Atomic-level characterization of self-regulatory mechanisms in large multidomain enzymes.

06/11/2019 - Jeff Purslow was selected to give a seminar on his research at the 2019 Gordon Research Conference on Computational Aspects of Biomolecular NMR....congrats!

04/19/2019 - Our assignment note is accepted for publication in Biomol NMR Assign.

Proud of Rochelle Dotas for having completed the backbone and side-chain resonance assignment of a 128kDa protein.

04/18/2019 - Our collaborative work with the Cademartiri group is accepted for publication in PNAS

We describe a low-cost strategy to produce transparent soils for root phenotyping in vivo.

04/17/2019 - Congratulations to Jeff Purslow who was awarded the Noble Hines Endowed Felloship and the ISU Teaching Excellence Award, and congratulations to Tim Egner who was awarded the ISU Teaching Excellence Award....WELL DONE!

01/10/2019 - Congratulation to Jolene Thimmesch who was awarded the Burnham Undergraduate Research Stipend for Summer 2019.

03/01/2019 - Congratulation to Tim Egner who was awarded a Student Travel Stipend to attend the 60th ENC conference.

01/10/2019 - Congratulation to Jolene Thimmesch who was awarded the Plagens Research Stipend for Spring 2019.

01/10/2019 - Jolene joins the lab

10/22/2018 - Tim Egner presents his work at the ACS 2018 Midwest Regional Meeting

10/13/2018 - The Venditti lab attends the 11^th GRASP Symposium on Protein and Biomolecular NMR

Proud of Jeff Purslow and Rochelle Dotas who won awards for best oral and poster presentation, respectively. WELL DONE!

10/11/2018 - Jeff's manuscript is accepted for publication in the Biophysical Journal....Congrats to everyone involved!

Here, we combine solution NMR and MD simulations to illuminate the kinetics, thermodynamics, and amplitude of the conformational dynamics of human Alkbh5. Our work resulted in the first atomic-resolution model of an AlkB protein in its disordered conformational state.

10/04/2018 - Our collaborative work with the Cademartiri group is accepted for publication in Nature Communications

We describe a low-cost strategy for sustainable scalable synthesis of sulfide nanocrystals.

07/06/2018 - Rochelle Dotas presents her work at the first CyHawk Symposium on Biomolecular NMR

06/01/2018 - Our assignment note is accepted for publication in Biomol NMR Assign.

Congratulation to Jeff Purslow for having completed our first backbone resonance assignment on a human enzyme!

04/11/2018 - Congratulation to Rochelle Dotas who was awarded the ISU Teaching Excellence Award. WELL DONE!

03/01/2018 - Welcome Valeria!

Valeria Sivo, a graduate student from the "Università degli Studi della Campania" (Italy), will spend 5 months in the lab to train in advanced NMR methods for investigating protein conformational dynamics.

01/26/2018 - Our collaborative work with the Tripsianes and Sgourakis groups is accepted for publication in Nature Communications

We describe an automated method for NMR structure determination of proteins.

01/09/2018 - Trang's first manuscript is accepted for publication in JBC....Congratulations!

We describe how a small molecule metabolite regulates the activity of enzyme I by acting both as a competitive inhibitor and as an allosteric stimulator of the enzyme.

11/20/2017 - Yeongseo joins the lab

10/17/2017 - Our assignment note is accepted for publication in Biomol NMR Assign.

Proud of Rochelle Dotas for having published the backbone resonance assignment of a 70kDa protein.

10/14/2017 - Proud of Rochelle Dotas who was selected for an oral presentation at GRASP, and of Jeff Purslow who brought the first award to the lab. WELL DONE!

10/13/2017 - The Venditti lab attends the 10^th GRASP Symposium on Protein and Biomolecular NMR

07/24/2017 - The Roy J. Carver Charitable Trust has funded our project entitled, "Identification of ligands of Enzyme I from the bacterial phosphotransferase system: a stride toward addressing bacterial infections and allosteric communication in proteins"

06/22/2017 - Tim's manuscript is accepted for publication in Angewandte Chemie

We show that mechanistic details on nanoparticle surface adsorption can be investigated by solution NMR in a hydrogel.

01/02/2017 - Jeff joins the lab

08/16/2016 - Bal joins the lab

12/21/2015 - Our review is accepted in Chemical Reviews

Congrats to Tim for his first publication. Let it be the first of a long series!

08/17/2015 - Trang joins the lab

06/24/2015 - Our QCI cryoprobe is here!

01/02/2015 - Tim joins the lab

01/02/2015 - Rochelle joins the lab

01/02/2015 - The Venditti Lab opens for business